Breaking news: Glucosamine supplements can lower CVD risks

(Medscape Excerpts)

Patients who regularly take glucosamine supplements may have a moderately lower risk for cardiovascular disease (CVD) events, results from 22 centers participating in the UK Biobank suggest.

Glucosamine use was associated with a 15% lower risk for total CVD events and a 9% to 22% lower risk for stroke, coronary heart disease and CVD death after adjustment for age, sex, body mass index, race, lifestyle factors, diet, medications, and other supplements.

A few other cohort studies have raised this question including the Vitamins and Lifestyle (VITAL) cohort study, in which high glucosamine use (at least 4 days per week for at least 3 years) was associated with a 17% lower adjusted total mortality risk.

Animal studies suggest the associations may be driven by the anti-inflammatory properties of glucosamine or that the popular supplement may mimic a low carbohydrate diet by decreasing glycolysis and increasing amino acid catabolism, the authors write in their article published online May 14 in BMJ.

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